abstract：:Liver fibrosis is scar tissue resulting from an uncontrolled wound-healing process in response to chronic liver injury. Liver damage generates an inflammatory reaction that activates hepatic stellate cells (HSC) that transdifferentiate from quiescent cells that control retinol metabolism to proliferative and migratory...

journal_title：Journal of pineal research

authors： Shajari S,Laliena A,Heegsma J,Tuñón MJ,Moshage H,Faber KN

更新日期：2015-10-01 00:00:00

abstract：:Melatonin (MEL) has been found in some medicinal and food plants, including grapevine, a commodity of particular interest for the production of wine, a beverage of economic relevance. It has also been suggested that MEL in wine may, at least in part, contribute to the health-promoting properties attributed to this bev...

journal_title：Journal of pineal research

authors： Vigentini I,Gardana C,Fracassetti D,Gabrielli M,Foschino R,Simonetti P,Tirelli A,Iriti M

更新日期：2015-05-01 00:00:00

abstract：:The circadian clock plays a vital role in physiology and behavior such as the sleep-wake cycle and blood pressure and hormone levels. Immune responses also display circadian rhythmicity and particularly pineal melatonin contributes to immunological processes. Little attention, however, is given to mechanisms underlyin...

journal_title：Journal of pineal research

authors： Ren DL,Li YJ,Hu BB,Wang H,Hu B

更新日期：2015-05-01 00:00:00

abstract：:Despite high in-hospital mortality associated with acute respiratory distress syndrome (ARDS), there is no effective therapeutic strategy. We tested the hypothesis that combined melatonin-mitochondria treatment ameliorates 100% oxygen-induced ARDS in rats. Adult male Sprague-Dawley rats (n = 40) were equally categoriz...

journal_title：Journal of pineal research

authors： Sun CK,Lee FY,Kao YH,Chiang HJ,Sung PH,Tsai TH,Lin YC,Leu S,Wu YC,Lu HI,Chen YL,Chung SY,Su HL,Yip HK

更新日期：2015-03-01 00:00:00

abstract：:The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade. Cigarette smoke (CS) is the most important risk factor in the development of COPD. In this study, we investigated the effects of melatonin on the development of COPD using a CS and lipopolysaccharide (LPS)-induc...

journal_title：Journal of pineal research

authors： Shin IS,Shin NR,Park JW,Jeon CM,Hong JM,Kwon OK,Kim JS,Lee IC,Kim JC,Oh SR,Ahn KS

更新日期：2015-01-01 00:00:00

abstract：:Cardiac tissue loss is one of the most important factors leading to the unsatisfactory recovery even after treatment of ischemic heart disease. Melatonin, a circadian molecule with marked antioxidant properties, protects against ischemia-reperfusion (IR) injury. In particular, the myocardial protection of melatonin is...

journal_title：Journal of pineal research

authors： Yang Y,Sun Y,Yi W,Li Y,Fan C,Xin Z,Jiang S,Di S,Qu Y,Reiter RJ,Yi D

更新日期：2014-11-01 00:00:00

abstract：:Melatonin, a major pineal secretory product, exerts a range of physiological and neuroprotective effects. However, the functional significance of melatonin in determining neural identity, and the mechanisms by which this may occur, is unknown. In this study, P19 cells were used as a model system and cell behavior was ...

journal_title：Journal of pineal research

authors： Chen X,Li X,Du Z,Shi W,Yao Y,Wang C,He K,Hao A

更新日期：2014-09-01 00:00:00

abstract：:Melatonin has been identified in primitive photosynthetic bacteria, fungi, plants, and animals including humans. Vegetables, fruits, cereals, wine, and beers all contain melatonin. However, the melatonin content in meats has not been reported previously. Here, for the first time, we report melatonin in meats, eggs, co...

journal_title：Journal of pineal research

authors： Tan DX,Zanghi BM,Manchester LC,Reiter RJ

更新日期：2014-09-01 00:00:00

abstract：:Grapes are an important economic crop and are widely cultivated around the world. Most grapes are grown in arid or semi-arid regions, and droughts take a heavy toll in grape and wine production areas. Developing effective drought-resistant cultivation measures is a priority for viticulture. Melatonin, an indoleamine, ...

journal_title：Journal of pineal research

authors： Meng JF,Xu TF,Wang ZZ,Fang YL,Xi ZM,Zhang ZW

更新日期：2014-09-01 00:00:00

abstract：:The aim was to examine the effect of perioperative melatonin treatment on clinical cardiac morbidity and markers of myocardial ischemia in patients undergoing elective surgery for abdominal aortic aneurism. Reperfusion injury results in increased cardiac morbidity in patients undergoing surgery for abdominal aortic an...

journal_title：Journal of pineal research

authors： Gögenur I,Kücükakin B,Panduro Jensen L,Reiter RJ,Rosenberg J

更新日期：2014-08-01 00:00:00

abstract：:Melatonin is part of the evolutionary conserved highly functional network in vertebrates. It plays a central role in the adaptative behavior of the animal to the environment, including entrainment of daily and annual physiological rhythms, reproductive behavior, food intake, locomotor activity, growth, and breeding pe...

journal_title：Journal of pineal research

authors： Lima-Cabello E,Díaz-Casado ME,Guerrero JA,Otalora BB,Escames G,López LC,Reiter RJ,Acuña-Castroviejo D

更新日期：2014-08-01 00:00:00

abstract：:No previous reports have described the effects of an increase in endogenous melatonin levels on plant yield and reproduction. Here, the phenotypes of melatonin-rich transgenic rice plants overexpressing sheep serotonin N-acetyltransferase were investigated under field conditions. Early seedling growth of melatonin-ric...

journal_title：Journal of pineal research

authors： Byeon Y,Back K

更新日期：2014-05-01 00:00:00

abstract：:Fetal intrauterine growth restriction (IUGR) is a serious pregnancy complication associated with increased rates of perinatal morbidity and mortality, and ultimately with long-term neurodevelopmental impairments. No intervention currently exists that can improve the structure and function of the IUGR brain before birt...

journal_title：Journal of pineal research

authors： Miller SL,Yawno T,Alers NO,Castillo-Melendez M,Supramaniam VG,VanZyl N,Sabaretnam T,Loose JM,Drummond GR,Walker DW,Jenkin G,Wallace EM

更新日期：2014-04-01 00:00:00

abstract：:In the current study, a fundamental question, that is, the mechanisms related to the beneficial effects of melatonin on mammalian embryonic development, was addressed. To examine the potential beneficial effects of melatonin on bovine embryonic development, different concentrations of melatonin (10(-11), 10(-9), 10(-7...

journal_title：Journal of pineal research

authors： Wang F,Tian X,Zhang L,Gao C,He C,Fu Y,Ji P,Li Y,Li N,Liu G

更新日期：2014-04-01 00:00:00

abstract：:Autophagy is an important survival pathway and participates in the host response to infection. Beneficial effects of melatonin have been previously reported in an animal model of acute liver failure (ALF) induced by the rabbit hemorrhagic disease virus (RHDV). This study was aimed to investigate whether melatonin prot...

journal_title：Journal of pineal research

authors： San-Miguel B,Crespo I,Vallejo D,Álvarez M,Prieto J,González-Gallego J,Tuñón MJ

更新日期：2014-04-01 00:00:00

abstract：:A major goal of plant biotechnology is to improve the nutritional qualities of crop plants through metabolic engineering. Melatonin is a well-known bioactive molecule with an array of health-promoting properties, including potent antioxidant capability. To generate melatonin-rich rice plants, we first independently ov...

journal_title：Journal of pineal research

authors： Byeon Y,Park S,Lee HY,Kim YS,Back K

更新日期：2014-04-01 00:00:00

abstract：:Aging is a multifactorial process that involves biochemical, structural, and functional changes in mitochondria. The ability of melatonin to palliate the alterations induced by aging is based on its chronobiologic, antioxidant, and mitochondrial effects. There is little information about the effects of melatonin on th...

journal_title：Journal of pineal research

authors： Martin-Cano FE,Camello-Almaraz C,Acuña-Castroviejo D,Pozo MJ,Camello PJ

更新日期：2014-03-01 00:00:00

abstract：:Preterm delivery is the leading cause of neonatal mortality and contributes to delayed physical and cognitive development in children. At present, there is no efficient therapy to prevent preterm labor. A large body of evidence suggests that intra-amniotic infections may be a significant and potentially preventable ca...

journal_title：Journal of pineal research

authors： Domínguez Rubio AP,Sordelli MS,Salazar AI,Aisemberg J,Bariani MV,Cella M,Rosenstein RE,Franchi AM

更新日期：2014-03-01 00:00:00

abstract：:An important role for melatonin in bone formation and restructuring has emerged, and studies demonstrate the multiple mechanisms for these beneficial actions. Statistical analysis shows that even with existing osteoporotic therapies, bone-related disease, and mortality are on the rise, creating a huge financial burden...

journal_title：Journal of pineal research

authors： Maria S,Witt-Enderby PA

更新日期：2014-03-01 00:00:00

abstract：:Lower global cognitive function scores are a common symptom of autism spectrum disorders (ASDs). This study investigates the effects of melatonin on hippocampal serine/threonine kinase signaling in an experimental ASD model. We found that chronic melatonin (1.0 or 5.0 mg/kg/day, 28 days) treatment significantly rescue...

journal_title：Journal of pineal research

authors： Tian Y,Yabuki Y,Moriguchi S,Fukunaga K,Mao PJ,Hong LJ,Lu YM,Wang R,Ahmed MM,Liao MH,Huang JY,Zhang RT,Zhou TY,Long S,Han F

更新日期：2014-01-01 00:00:00

abstract：:N-acetylserotonin methyltransferase (ASMT) is the final enzyme in a biosynthetic pathway that produces melatonin. ASMT may play a rate-limiting role in the production of this bioactive molecule in plants. There are three ASMT genes (ASMT1-ASMT3) in the rice genome, but only ASMT1 has been functionally characterized. A...

journal_title：Journal of pineal research

authors： Park S,Byeon Y,Back K

更新日期：2013-11-01 00:00:00

abstract：:Previous studies proved that melatonin protected against secondary brain damage by modulating oxidative stress after experimental subarachnoid hemorrhage (SAH), but it has not been evaluated yet about its effects on inflammatory pathway and secondary cognitive dysfunction in SAH model. This study was undertaken to eva...

journal_title：Journal of pineal research

authors： Wang Z,Wu L,You W,Ji C,Chen G

更新日期：2013-11-01 00:00:00

abstract：:Transgenic rice plants overexpressing a sheep serotonin N-acetyltransferase led to an enhanced production of melatonin with various physiological effects, including seminal root elongation and resistance against cold and oxidative stress, which raises the possibility that melatonin may alter gene expression profiles i...

journal_title：Journal of pineal research

authors： Byeon Y,Park S,Kim YS,Back K

更新日期：2013-11-01 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) is harmful to the cardiovascular system and causes mitochondrial oxidative stress. Numerous data indicate that the JAK2/STAT3 signaling pathway is specifically involved in preventing myocardial IRI. Melatonin has potent activity against IRI and may regulate JAK2/STAT3 signaling. This ...

journal_title：Journal of pineal research

authors： Yang Y,Duan W,Jin Z,Yi W,Yan J,Zhang S,Wang N,Liang Z,Li Y,Chen W,Yi D,Yu S

更新日期：2013-10-01 00:00:00

abstract：:UV radiation (UVR) induces serious structural and functional alterations in human skin leading to skin aging and carcinogenesis. Reactive oxygen species are key players in UVR-mediated photodamage and induce the DNA-base-oxidized, intermediate 8-hydroxy-2'-deoxyguanosine (8-OHdG). Herein, we report the protective acti...

journal_title：Journal of pineal research

authors： Fischer TW,Kleszczyński K,Hardkop LH,Kruse N,Zillikens D

更新日期：2013-04-01 00:00:00

abstract：:The purpose of this study was to determine whether melatonin treatment would mitigate retinal ganglion cell (RGC) death in the developing retina following a hypoxic insult. Lipid peroxidation (LPO), glutathione (GSH), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) concentrations, expression of vascular end...

journal_title：Journal of pineal research

authors： Kaur C,Sivakumar V,Robinson R,Foulds WS,Luu CD,Ling EA

更新日期：2013-03-01 00:00:00

abstract：:Melatonin has shown particular promise as a neuroprotective agent to prevent motoneuron death in animal models of both amyotrophic lateral sclerosis (ALS) and spinal cord injuries (SCI). However, an understanding of the roles of endogenous melatonin receptors including MT1, MT2, and orphan G-protein receptor 50 (GPR50...

journal_title：Journal of pineal research

authors： Das A,Wallace G 4th,Reiter RJ,Varma AK,Ray SK,Banik NL

更新日期：2013-01-01 00:00:00

abstract：:Epigenetic alterations have emerged as an important mechanism involved in tumorigenesis. The epigenetic impact of DNA methylation in various types of human cancer is not completely understood. Previously, we observed melatonin-induced differential expression of miRNA and miRNA-related genes in human breast cancer cell...

journal_title：Journal of pineal research

authors： Lee SE,Kim SJ,Yoon HJ,Yu SY,Yang H,Jeong SI,Hwang SY,Park CS,Park YS

更新日期：2013-01-01 00:00:00

abstract：:The effect of light on melatonin biosynthesis was examined in detached rice (Oryza sativa cv. Asahi) leaves during the senescence process. The detached leaves were exposed to senescence treatment either in constant darkness or in constant light, and subjected to HPLC analysis for melatonin and its precursors. Higher m...

journal_title：Journal of pineal research

authors： Byeon Y,Park S,Kim YS,Park DH,Lee S,Back K

更新日期：2012-08-01 00:00:00

abstract：:Melatonin regulates mitogen-activated protein kinase (MAPK) and Akt signaling pathways. The MAPK family mainly includes extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK). Our previous study documented that melatonin delays osteoblast proliferation; however, the mechanism of action of ...

journal_title：Journal of pineal research

authors： Liu L,Zhu Y,Xu Y,Reiter RJ

更新日期：2012-08-01 00:00:00

abstract：:Possible role of melatonin in the germination of negatively photoblastic and thermosensitive seeds of Phacelia tanacetifolia Benth was studied. Final germination percentage (FGP) was determined in the presence or absence of light at various temperatures, ranging from 0 to 40°C. The highest FGP was determined as 48.7% ...

journal_title：Journal of pineal research

authors： Tiryaki I,Keles H

更新日期：2012-04-01 00:00:00

abstract：:Melatonin biosynthesis was examined in Sekiguchi mutant rice lacking functional tryptamine 5-hydroxylase (T5H) activity, which is the terminal enzyme for serotonin biosynthesis in rice. During senescence process, the leaves of Sekiguchi mutant rice produced more tryptamine and N-acetyltryptamine compared with the wild...

journal_title：Journal of pineal research

authors： Park S,Lee K,Kim YS,Back K

更新日期：2012-03-01 00:00:00

abstract：:Oxidative stress is involved in ischemia-reperfusion injury and allograft rejection after transplantation. We studied two well-known antioxidants, melatonin and ascorbic acid (AA), in relation to the survival of a pancreas transplantation model without immunosuppression. Forty-eight Landrace pigs were divided into thr...

journal_title：Journal of pineal research

authors： García-Gil FA,Albendea CD,Escartín J,Lampreave F,Fuentes-Broto L,Roselló-Catafau J,López-Pingarrón L,Reiter RJ,Alvarez-Alegret R,García JJ

更新日期：2011-11-01 00:00:00

abstract：:A link between endotoxemia and nonalcoholic fatty liver disease (NAFLD) has been demonstrated in human and rodent animals. Nevertheless, the molecular mechanisms of endotoxin-evoked NAFLD remain poorly understood. We hypothesize that reactive oxygen species (ROS) mediate lipopolysaccharide (LPS)-evoked hepatic lipid a...

journal_title：Journal of pineal research

authors： Chen X,Zhang C,Zhao M,Shi CE,Zhu RM,Wang H,Zhao H,Wei W,Li JB,Xu DX

更新日期：2011-11-01 00:00:00

abstract：:Resistance inducers are a class of agrochemicals, including benzothiadiazole and chitosan, which activate the plant own defence mechanisms. In this work, open-field treatments with plant activators were performed on two red grape (Vitis vinifera L.) varieties cultivated in different localities, Groppello (Brescia, Lom...

journal_title：Journal of pineal research

authors： Vitalini S,Gardana C,Zanzotto A,Fico G,Faoro F,Simonetti P,Iriti M

更新日期：2011-10-01 00:00:00

abstract：:Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties. There are also experimental and clinical data supporting an analgesic role of melatonin. In experimental studies, melatonin sho...

journal_title：Journal of pineal research

authors： Wilhelmsen M,Amirian I,Reiter RJ,Rosenberg J,Gögenur I

更新日期：2011-10-01 00:00:00

abstract：:In previous studies, we have shown that mitochondrial respiratory chain (MRC) activity is decreased in patients with nonalcoholic steatohepatitis and in ob/ob mice and that peroxynitrite plays a pathogenic role. The present study examined whether melatonin, a peroxynitrite scavenger, prevents: (i) the in vitro effects...

journal_title：Journal of pineal research

authors： Solís-Muñoz P,Solís-Herruzo JA,Fernández-Moreira D,Gómez-Izquierdo E,García-Consuegra I,Muñoz-Yagüe T,García Ruiz I

更新日期：2011-08-01 00:00:00

abstract：:Melatonin signaling dysfunction has been associated with the etiology of adolescent idiopathic scoliosis (AIS). Genetic analysis has also associated the occurrence of AIS with the MT2 gene. Thus, we determined whether there is abnormality in the protein expression of melatonin receptors (MT) in AIS osteoblasts. In thi...

journal_title：Journal of pineal research

authors： Man GC,Wong JH,Wang WW,Sun GQ,Yeung BH,Ng TB,Lee SK,Ng BK,Qiu Y,Cheng JC

更新日期：2011-05-01 00:00:00

abstract：:Incorporation of new therapeutic agents remains as a major challenge for treatment of patients with malignant haematological disorders. Melatonin is an indolamine without relevant side effects. It has been shown previously to exhibit synergism with several chemotherapeutic drugs in Ewing sarcoma cells by potentiating ...

journal_title：Journal of pineal research

authors： Casado-Zapico S,Martín V,García-Santos G,Rodríguez-Blanco J,Sánchez-Sánchez AM,Luño E,Suárez C,García-Pedrero JM,Menendez ST,Antolín I,Rodriguez C

更新日期：2011-04-01 00:00:00

abstract：:Recent investigations have demonstrated that melatonin influences carbohydrate metabolism mediated by insulin-inhibiting effects on pancreatic β-cells. This study evaluated whether melatonin has also an effect on pancreatic α-cells and glucagon expression as well as the glucagon secretion in vitro and in vivo. Glucago...

journal_title：Journal of pineal research

authors： Bähr I,Mühlbauer E,Schucht H,Peschke E

更新日期：2011-04-01 00:00:00